Exenatide Acetate

Yintoni i-Exenatide Acetate?

I-Exenatide acetate yikhemikhali eyenziwe lula ye-exendin-4, ikhemikhali ye-peptide eyenziwe zi-organs ze-salivary ze-Gila beast reptile. Yi-glucagon-like peptide-1 (GLP-1) receptor agonist, kwaye oko kuthetha ukuba idibana kwaye isebenzise i-GLP-1 receptor kwi-pancreas. Olu sebenze luvuselela ukufika kwe-insulin kwiiseli ze-beta, enceda ekunciphiseni amanqanaba e-glucose.

Ulwazi olusisiseko

Igama leMveliso: Exenatide acetate

I-CAS: 141732-76-5

MF:C186H286N50O62S

UMM: 4244.60796

I-EINECS: 1592732-453-0

Inombolo ye-MDL: MFCD08704781

ifom eSolid

umbala oMhlophe ukuya kwi-Off-Mhlophe

Ubunyulu: 98% +

Iphakheji: 1g; 5g; 25g

Isetyenzisiweyo: Uphando lwaseLab

Uzinzo: Zinzile

Ifomula yolwakhiwo:

Iinkcukacha kunye neeParameters:

Ukwakhiwa kweMikhali:

I-Exenatide Acetate , ehlelwe ngeenkqubo ze-biotechnology eziphambili, yenziwe ngee-amino acids. Olu lungiselelo lubalulekileyo luquka i-alanine, i-glycine, i-histidine, i-leucine, i-proline, kunye ne-serine, phakathi kwezinye. Iipropati ze-pharmacological ze-compound kunye nokusebenza kakuhle konyango kuphuculwa lulungiselelo oluchanekileyo lwee-amino acids zayo. Yinto elula eyenziwe nge-exendin-4, ikhemikhali ye-peptide eyenziwe zi-organs ze-salivary ye-Gila beast reptile. Yenziwe ngee-amino acids ezingama-39 kwaye ineresiphi ye-sub-atomic ye-C183H288N42O53. Umthwalo we-sub-atomic we-exenatide acetic acid derivation yi-4186.68.

Ukwakhiwa kweekhemikhali ze-exenatide acetate kufana kakhulu ne-exendin-4. Ukwahlukana kuphela kukuba i-acetate ye-exenatide ineqela le-acetyl elifakwe kwi-lysine residue kwindawo ye-28. Eli qela le-acetyl lenza i-acetate ye-exenatide iqine kwaye ixhathise ukuthotywa kwe-enzymes.

I-Exenatide acetate ngumgubo omhlophe ukuya komhlophe onyibilikayo emanzini. Idla ngokwenziwa njengesisombululo sokujova. Iimpawu ezaziwayo ze-Exenatide acetate ziquka ukurhawuzelela, ukukhafula, ukukhululeka kwamathumbu kunye nobuhlungu besisu. Ezi ziphumo zihlala zithambile kwaye ziyanyamalala kwisithuba seenyanga ezintandathu. Ezinye iziphumo ebezingalindelekanga ziquka ukudinwa, isiyezi kunye nentloko ebuhlungu.

I-Exenatide acetate lunyango lwesifo seswekile sohlobo lwesibini olukhuselekileyo nolusebenzayo. Isetyenziswa rhoqo xa ixutywa nemithi eyahlukeneyo, efana ne-metformin okanye i-sulfonylureas. Ikwasetyenziswa rhoqo ukunyanga ukutyeba.

Indima kunye noMsebenzi:

Isetyenziswa kunyango lwe-2 yeswekile kuba ibonakalisa iimpembelelo ze-GLP-1. Ngokucutha kunye nokusebenzisa i-GLP-1 receptor, i-exenatide acetic acid derivation ivuselela ukufika kwe-insulin kwiiseli ze-beta, icofa umva ukucocwa kwesisu, kwaye inqanda indlala. Ezi mpembelelo zinceda ukuthoba amanqanaba eglucose kwaye ziphuhlise ngakumbi ulawulo lweglucose.

I-Exenatide acetate isetyenziswa kakhulu xa idityaniswe nezinye iziyobisi, ezifana ne-metformin okanye i-sulfonylureas. Oku kungenxa yokuba ukuveliswa kwe-exenatide acetic acid akunyanzelekanga ekunciphiseni amanqanaba eglucose kubantu abangenayo i-insulin.

Ukongeza, ukutyeba kakhulu ngamanye amaxesha kunyangwa nge-exenatide acetate. Oku kungenxa yokuba inokucothisa ukuphelelwa yisisu kwaye icinezele ukutya, zombini ezi zinto zinokunceda abantu banciphise ubunzima.

Umsebenzi kuNyango lweSifo seswekile sesi-2

• Lunyango olukhuselekileyo nolusebenzayo lwesifo seswekile sohlobo lwesibini. Lusetyenziswa rhoqo xa luxutywa nemithi eyahlukeneyo, efana ne-metformin okanye i-sulfonylureas. Kwiiveki ezingama-24, kwabonakala ukuba i-exenatide acetate yehlise amanqanaba e-HbA1c nge-1.0 ukuya kwi-1.5 ekhulwini.

• Kwezinye iimeko, ikwasetyenziselwa ukunyanga ukutyeba kakhulu. Oku kungenxa yokuba i-exenatide acetic acid derivation iyayithintela indlala kwaye ibuyisela umva ukuphuma kwesisu, nto leyo enokubangela ukwehla kobunzima. Kwiiveki ezingama-24, i-exenatide acetate ifunyenwe inciphisa ubunzima bomzimba ngomyinge we-4.5 kg.

• Lunyango olukhuselweyo nolusebenzayo kuhlobo lwe-2 yeswekile kunye ne-corpulence. Isebenza ngokulinganisa iimpembelelo ze-GLP-1, ikhemikhali eyenziwe yinkqubo encinci yokwetyisa

I-Exenatide acetate lunyango olukhuselekileyo nolunamandla kwisifo seswekile sohlobo lwesibini kunye nokuqina komzimba. Isebenza ngokulinganisa iziphumo zehomoni i-GLP-1 eveliswa ngamathumbu amancinci.

Inkqubo yoHlanganiso:

I-Exenatide acetate yi-synthetic analog ye-exendin-4, i-peptide hormone eveliswa yi-Gila monster lizard. Yenziwa kusetyenziswa inkqubo ebizwa ngokuba yi-solid-phase peptide synthesis (SPPS).

I-SPPS yindlela yokwenza iipeptides ngokudibanisa i-amino acids kancinci kancinci kwi-peptide chain ekhulayo. Le nkqubo yenziwa ngenkxaso eqinileyo, edla ngokuba yi-resin bead. Ii-amino acids zongezwa kwi-resin bead ngokulandelelana okufunekayo, kwaye i-amino acid nganye idityaniswe ne-peptide chain ekhulayo kusetyenziswa i-chemical reaction.

Nje ukuba ikhonkco lepeptide ligqityiwe, liyacandwa kwi-resin bead kwaye licocwe. I-peptide ecocekileyo ke i-acetylated ukwenza i-acetate exenatide.

• Ukucwangciswa kweGum Globule: Inyathelo lokuqala kukuseta i-tar dot. I-pitch dot yenziwa rhoqo nge-polystyrene okanye i-polyethylene glycol. I-gum dab isebenza nge-linker particle, evumela ukuba ii-amino acids ziqhagamshelwe kwi-gum globule.

• Ukudibanisa i-Amino Eyintloko Ebolayo: I-amino ebolayo ephambili idityaniswe ne-pitch dot kusetyenziswa impendulo yokwenziwa. I-amino ebolayo iqaliswa rhoqo kusetyenziswa i-coupling reagent, umzekelo, i-dicyclohexylcarbodiimide (DCC) okanye i-1-hydroxybenzotriazole (HOBt).

• Ukudibanisa ii-Amino Acids ezigqithisileyo: Ii-amino acids ezigqithisileyo zidityaniswe ne-peptide chain ephuhlisayo nganye nganye, kubandakanya impendulo efanayo yezinto ezikwi-sync 2. Isicelo se-amino asikagqitywa ngokupheleleyo yiqela elifanelekileyo le-peptide.

• Ukuqhekeka kwePeptide kwiTar Globule: Xa ikhonkco lepeptide ligqityiwe, liyanqunyulwa kwi-sap dab kusetyenziswa impendulo edibeneyo. Impendulo yokuqhekeka igqitywa rhoqo kusetyenziswa iindawo ezinamandla amakhulu, umzekelo, i-trifluoroacetic corrosive (TFA).

• Ukucocwa kwePeptide: I-peptide eqhekekileyo icocwa kusetyenziswa i-chromatography kunye ne-crystallization, phakathi kwezinye iindlela.

• I-Acetylation yePeptide: I-peptide ecociweyo ixutywe ne-acetylated ukuze ifake i-exenatide acetic acid derivation. Impendulo ye-acetylation idla ngokwenziwa kusetyenziswa i-acidic anhydride okanye i-acetyl chloride.

Imigangatho yoMgangatho:

I-Exenatide acetate liyeza le-peptide elisetyenziselwa ukunyanga isifo seswekile sohlobo lwesibini kunye nokutyeba kakhulu. Liyi-analog yokwenziwa ye-exendin-4, i-hormone eveliswa yi-Gila monster lizard. I-Exenatide acetate yenziwa kusetyenziswa inkqubo ebizwa ngokuba yi-solid-phase peptide synthesis.

Umgangatho we-acetate ye-exenatide ibaluleke kakhulu kukhuseleko kunye nokusebenza kwayo. Le ilandelayo yeminye yemigangatho yomgangatho wemveliso esetyenziswa kwi-acetate ye-exenatide:

• Ubume: Uhlobo lwe-exenatide acetate luqinisekiswa ngeendlela ezahlukeneyo zengqiqo, ezifana ne-superior execution fluid chromatography (HPLC) kunye ne-mass spectrometry.

• Ubunyulu: Ukungangcoli kwayo kusesemoyeni ngokuqikelela ukuba ingakanani ingcoliseko kwimveliso yeyeza. Ingcoliseko idla ngokuvavanywa kusetyenziswa i-HPLC.

• Amandla: Amandla ayo okubopha nokusebenza kwe-GLP-1 receptor asetyenziselwa ukumisela amandla ayo. Amandla adla ngokudluliselwa kwiiyunithi ze-IU/mg.

• Ukungazali: Liyeza elingenazintsholongwane.

I-Yihui, njengomvelisi ohamba phambili, ibambelela kwimigangatho engqongqo yomgangatho wokuqinisekisa ukugqwesa kwe-Exenatide Acetate. Iinkqubo zethu zemveliso zihambelana nebenchmarks zamazwe ngamazwe, kwaye amaziko ethu aqhayisa ngeziqinisekiso ezibandakanya ISO, Kosher, Halal. Ezi ziqinisekiso zigxininisa ukuzinikela kwethu ekuziseni imveliso ehlangabezana neyona migangatho iphezulu yoshishino kunye neemfuno zolawulo.

Iinkalo zeSicelo kuShishino olwahlukeneyo :

I-Exenatide acetate yi-GLP-1 receptor agonist esetyenziselwa ukunyanga isifo seswekile sohlobo lwesibini kunye nobunzima. Yinto elula eyenziwe yi-exendin-4, ikhemikhali eyenziwe sisilwanyana esirhubuluzayo iGila. Ihlala isetyenziswa xa ixutywa namayeza ahlukeneyo, njenge-metformin okanye i-sulfonylureas.

Ngaphandle kokusetyenziswa kwayo kwishishini lamachiza, nayo iphandelwe ukusetyenziswa kumalinge awohlukeneyo, kuquka:

• Unyango lwezilwanyana: Isifo seswekile ezinjeni nakwiikati sinokunyangwa ngempumelelo nge-exenatide acetate. Sisetyenziswa rhoqo xa sidityaniswe namayeza ahlukeneyo, njenge-insulin.

• Izinto zokuthambisa: Ulusu lubonakaliswe ukuba luxhamla kwimiphumo yokulwa nokwaluphala ye-exenatide acetate. Lukhunjulwa ukuba lusebenza ngokuvuselela uphuhliso lwe-collagen kunye ne-elastin, eziziiproteni ezimbini ezinoxanduva lokuguquguquka nokuqina kolusu.

• ukwehlisa iikhilogram: Kuye kwabonakala kuluncedo ekuphuculeni ukwehla kobunzima kubantu abatyebe kakhulu okanye abatyebileyo. Kukhunjulwa ukusebenza ngokunciphisa inkanuko nokunciphisa ukuphuma kwesisu.

• Unyango lwezinye izifo ze-metabolic: Lunokuba namandla ekunyangeni ezinye izifo ze-metabolic, ezifana nesifo sesibindi esinamafutha angenatywala kunye nesifo se-polycystic ovary disorder.

• Izifo ezibangela ukonakala kwemithambo-luvo ziyanyangwa: Kwizifundo zezilwanyana, iziphumo zokukhusela imithambo-luvo ze-exenatide acetate ziye zabonakaliswa. Kukhunjulwa ukuba isebenza ngokunciphisa ukuxhaphaka kunye noxinzelelo lwe-oxidative.

• Unyango lwesifo: Kuye kwabonakaliswa ukuba inempembelelo yomhlaza kwizifundo zezidalwa. Kukhunjulwa ukuba isebenza ngokuthintela uphuhliso lweeseli zesifo kunye nokuqhubela phambili ukubulawa kweeseli ezikhulayo ezinobungozi.

Ukupakisha kunye nokuhambisa ngenqanawe

Ukupakisha:

1kg/ibhegi yefoyile;5kg/ibhokisi;25kg/igubu lefayibha; okanye ukupakisha njengesicelo sakho.

Ngokwezifiso:

l Ilogo eyenzelwe wena

l Ukupakishwa okulungiselelweyo

l Ukwenza umzobo

Ukuhambisa ngenqanawe:

NgeCourier; NgoMoya okanye ngolwandle, ngokweemfuno zakho

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